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Article

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.

Journal of cell science - 1 Apr 2010

Hayakawa Tomohiro, Zhang Fan, Hayakawa Noriyo, Ohtani Yasuko, Shinmyozu Kaori, Nakayama Jun-ichi, Andreassen Paul R

Abstract excerpt

PALB2 physically and functionally connects the proteins encoded by the BRCA1 and BRCA2 breast and ovarian cancer genes into a DNA-damage-response network. However, it remains unclear how these proteins associate with chromatin that contains damaged DNA. We show here that PALB2 binds directly to a conserved chromodomain protein, MRG15, which is a component of histone acetyltransferase-deacetylase complexes. This...

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Source

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Identifiers

PMID: 20332121
DOI: 10.1242/jcs.060178
PMCID: PMC2844321

Genes

PALB2
BRCA2
BRCA1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.PMID 20332121Read ↗

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