Article
A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.
Glycobiology - 23 May 2022
Missaghian Parisa, Dierker Tabea, Khosrowabadi Elham, Axling Fredrik, Eriksson Inger, Ghanem Abdurrahman, Kusche-Gullberg Marion, Kellokumpu Sakari, Kjellén Lena
Abstract excerpt
NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 amino acids, here designated NDST1A, a shorter form containing 825 amino acids (NDST1B) is synthesized after alternative splicing of the NDST1 mRNA. NDST1B is mostly expressed at a low level,...
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