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Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy

10 Aug 2016

Abstract excerpt

Hematopoietic stem cell (HSC) transplantation can cure diverse diseases of the blood system, including hematologic malignancies, anemias, and autoimmune disorders. However, patients must undergo toxic conditioning regimens that use chemotherapy and/or radiation to eliminate host HSCs and enable donor HSC engraftment. Previous studies have shown that anti-c-Kit monoclonal antibodies deplete HSCs from bone marrow...

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PMID: 27510901
DOI: 10.1126/scitranslmed.aae0501

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