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Article

Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice

3 Sept 2010

Abstract excerpt

Inherited hematologic defects that lack an in vivo selective advantage following gene correction may benefit from effective yet minimally toxic cytoreduction of endogenous hematopoietic stem cells (HSCs) prior to transplantation of gene-modified HSCs. We studied the efficacy of administering a novel sequential treatment of parenteral ACK2, an antibody that blocks KIT, followed by low-dose irradiation (LD-IR) for...

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PMID: 20813896
DOI: 10.1182/blood-2010-07-295949

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