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Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation.

Cell stem cell - 3 Aug 2017

Abbuehl Jean-Paul, Tatarova Zuzana, Held Werner, Huelsken Joerg

Abstract excerpt

Hematopoietic stem cell (HSC) transplantation represents a curative treatment for various hematological disorders. However, delayed reconstitution of innate and adaptive immunity often causes fatal complications. HSC maintenance and lineage differentiation are supported by stromal niches, and we now find that bone marrow stroma cells (BMSCs) are severely and permanently damaged by the pre-conditioning irradiation...

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PMID: 28777945
DOI: 10.1016/j.stem.2017.07.004

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ENG

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