Article

cMPL-Based Purification and Depletion of Human Hematopoietic Stem Cells: Implications for Pre-Transplant Conditioning

2024-02-28

Abstract excerpt

The transplantation of gene-modified autologous hematopoietic stem and progenitor cells (HSPCs) offers a promising therapeutic approach for hematological and immunological disorders. However, this strategy is often limited by the toxicities associated with traditional conditioning regimens. Antibody-based conditioning strategies targeting cKIT and CD45 antigens have shown potential in mitigating these toxicities,...

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Literature Corpus work: 7465b09e-8b5b-5889-b335-990ad4ae29fa
DOI: 10.1101/2024.02.24.581887

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