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Article

Innovative Cell-Based Therapies and Conditioning to Cure RAG Deficiency.

Frontiers in immunology - 1 Jan 2020

Villa Anna, Capo Valentina, Castiello Maria Carmina

Abstract excerpt

Genetic defects in recombination activating genes (RAG) 1 and 2 cause a broad spectrum of severe immune defects ranging from early severe and repeated infections to inflammation and autoimmune manifestations. A correlation between in vitro recombination activity and immune phenotype has been described. Hematopoietic cell transplantation is the treatment of care; however, the availability of next generation...

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Identifiers

PMID: 33329604
DOI: 10.3389/fimmu.2020.607926
PMCID: PMC7711106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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