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Article

Intrinsic protein disorder could be overlooked in cocrystallization conditions: An SRCD case study.

Protein science : a publication of the Protein Society - 1 Nov 2016

Németh Eszter, Balogh Ria K, Borsos Katalin, Czene Anikó, Thulstrup Peter W, Gyurcsik Béla

Abstract excerpt

X-ray diffractometry dominates protein studies, as it can provide 3D structures of these diverse macromolecules or their molecular complexes with interacting partners: substrates, inhibitors, and/or cofactors. Here, we show that under cocrystallization conditions the results could reflect induced protein folds instead of the (partially) disordered original structures. The analysis of synchrotron radiation...

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PMID: 27508941
DOI: 10.1002/pro.3010
PMCID: PMC5079248

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