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Article

Investigating the structural stability of the Tup1-interaction domain of Ssn6: evidence for a conformational change on the complex.

Proteins - 1 Jan 2008

Palaiomylitou Maria, Tartas Athanassios, Vlachakis Dimitrios, Tzamarias Dimitris, Vlassi Metaxia

Abstract excerpt

Ssn6, a tetratricopeptide repeat (TPR) containing protein, associates with the Tup1 repressor to form a global transcriptional co-repressor complex, which is conserved across species. The three N-terminal TPR repeats of Ssn6, out of a total of 10, are involved in this particular interaction. Our previously reported 3D-modeling and mutagenesis data suggested that the structural integrity of TPR1 and its correct...

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Identifiers

PMID: 17634984
DOI: 10.1002/prot.21489

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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