Article
The Two-State Prehensile Tail of the Antibacterial Toxin Colicin N.
Biophysical journal - 17 Oct 2017
Johnson Christopher L, Solovyova Alexandra S, Hecht Olli, Macdonald Colin, Waller Helen, Grossmann J Günter, Moore Geoffrey R, Lakey Jeremy H
Abstract excerpt
Intrinsically disordered regions within proteins are critical elements in many biomolecular interactions and signaling pathways. Antibacterial toxins of the colicin family, which could provide new antibiotic functions against resistant bacteria, contain disordered N-terminal translocation domains (T-domains) that are essential for receptor binding and the penetration of the Escherichia coli outer membrane. Here...
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