Article
Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2001
Young L C, Campling B G, Cole S P, Deeley R G, Gerlach J H
Abstract excerpt
Previously (L. C. Young et al., Clin. Cancer Res., 5: 673-680, 1999), we found, in a panel of 23 lung cancer cell lines that had not been selected for in vitro drug resistance, that the mRNA levels of MRP3 and MRP1, two members of the ATP-binding cassette superfamily of transport proteins, correlated with resistance to doxorubicin, vincristine, VP-16, and cis-diamminedicholoroplatinum(II). To extend these...
Topics
- Amidohydrolases
- Antineoplastic Agents
- Blotting, Western
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Cell Membrane
- DNA-Binding Proteins
- Dihydrolipoyllysine-Residue Acetyltransferase
- Electrophoresis, Polyacrylamide Gel
- Fungal Proteins
- Humans
- Immunoglobulin G