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Article

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2010

Xu Shuhua, Weerachayaphorn Jittima, Cai Shi-Ying, Soroka Carol J, Boyer James L

Abstract excerpt

Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. MRP4/Mrp4 undergoes adaptive upregulation in response to oxidative and cholestatic liver injury in human and animal models of cholestasis. However, the molecular mechanism of this regulation...

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Identifiers

PMID: 20395535
DOI: 10.1152/ajpgi.00522.2010
PMCID: PMC2904108

Genes

ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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