Article
Farnesoid X receptor activates transcription of the phospholipid pump MDR3.
The Journal of biological chemistry - 19 Dec 2003
Huang Li, Zhao Annie, Lew Jane-L, Zhang Theresa, Hrywna Yaroslav, Thompson John R, de Pedro Nuria, Royo Inmaculada, Blevins Richard A, Peláez Fernando, Wright Samuel D, Cui Jisong
Abstract excerpt
The human multidrug resistance gene MDR3 encodes a P-glycoprotein that belongs to the ATP-binding cassette transporter family (ABCB4). MDR3 is a critical trans-locator for phospholipids across canalicular membranes of hepatocytes, evidenced by the fact that human MDR3 deficiencies result in progressive familial intrahepatic cholestasis type III. It has been reported previously that MDR3 expression is modulated by...
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