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Article

Human primary biliary cirrhosis-susceptible allele of rs4979462 enhances TNFSF15 expression by binding NF-1.

Human genetics - 1 Jul 2015

Hitomi Yuki, Kawashima Minae, Aiba Yoshihiro, Nishida Nao, Matsuhashi Mika, Okazaki Hitoshi, Nakamura Minoru, Tokunaga Katsushi

Abstract excerpt

A genome-wide association study (GWAS) identified tumor necrosis factor superfamily member 15 (TNFSF15) as the strongest associated gene with susceptibility to primary biliary cirrhosis (PBC) outside the HLA loci in the Japanese population. However, causal functional variants of the TNFSF15 locus and the molecular mechanism underlying disease susceptibility have not been clarified. Here, to identify the...

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Identifiers

PMID: 25899471
DOI: 10.1007/s00439-015-1556-3

Genes

TNFSF15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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