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Article

Substrain-Dependent Differences in Doxorubicin-Induced Cardiotoxicity in Adult C57BL/6 Mice.

Cardiovascular toxicology - 23 Dec 2025

Daniel Mary R, Grant Marianne K O, Dabour Mohamed S, Razzoli Maria, Souza-Neto Fernando, van Berlo Jop H, Bartolomucci Alessandro, Zordoky Beshay N

Abstract excerpt

Doxorubicin (DOX)-induced cardiotoxicity is widely studied using C57BL/6 mice. However, potential substrain differences between C57BL/6J (6J) and C57BL/6N (6N) remain unexamined. Comparative studies are needed to improve preclinical reproducibility and translation. Fifteen-week-old male 6N and 6J mice received either DOX (8 mg/kg/week for 3 weeks) or saline. Body weight was monitored weekly, followed by...

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Identifiers

PMID: 41432818
DOI: 10.1007/s12012-025-10076-6
PMCID: PMC12727845

Genes

STAT3

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