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Article

Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2011

Wang Jianxun, Wang Qianwen, Watson Lewis J, Jones Steven P, Epstein Paul N

Abstract excerpt

Cardiac failure is associated with increased levels of oxidized DNA, especially mitochondrial (mtDNA). It is not known if oxidized mtDNA contributes to cardiac dysfunction. To test if protection of mtDNA can reduce cardiac injury, we produced transgenic mice with cardiomyocyte-specific overexpression of the DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1) isoform 2a. In one line of mice, the transgene...

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Identifiers

PMID: 21873502
DOI: 10.1152/ajpheart.00157.2011
PMCID: PMC3213972

Genes

OGG1

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