Article
Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2011
Shinohara Tamako, Nemoto Yasuhiro, Kanai Takanori, Kameyama Kaori, Okamoto Ryuichi, Tsuchiya Kiichiro, Nakamura Tetsuya, Totsuka Teruji, Ikuta Koichi, Watanabe Mamoru
Abstract excerpt
We have previously demonstrated that IL-7 is essential for the persistence of colitis as a survival factor of colitogenic IL-7Rα-expressing memory CD4(+) T cells. Because IL-7Rα is broadly expressed on various immune cells, it is possible that the persistence of colitogenic CD4(+) T cells is affected by other IL-7Rα-expressing non-T cells. To test this hypothesis, we conducted two adoptive transfer colitis...
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