Article
CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype.
International immunology - 1 Mar 2008
Guo Zijin, Jang Myoung Ho, Otani Kazuhiro, Bai Zhongbin, Umemoto Eiji, Matsumoto Masanori, Nishiyama Mika, Yamasaki Mikako, Ueha Satoshi, Matsushima Kouji, Hirata Takako, Miyasaka Masayuki
Abstract excerpt
CD4(+)CD25(+) regulatory T cells (Tregs) have been implicated in the suppression of pathogenic responses to both self- and non-self-antigens in the intestine. However, their precise properties and functions in the gut, as well as the molecular basis of their recruitment to the gut, are poorly understood. Here, we found that most of the CD4(+)CD25(+) T cells in the small intestinal lamina propria (LP) express...
Topics
- Animals
- Antigens, CD
- CD4-Positive T-Lymphocytes
- CTLA-4 Antigen
- Chemokine CCL17
- Chemokine CCL22
- Dendritic Cells
- Forkhead Transcription Factors
- Gene Expression Regulation
- Immunologic Memory