Article
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Cell reports - 16 Aug 2016
Shlien Adam, Raine Keiran, Fuligni Fabio, Arnold Roland, Nik-Zainal Serena, Dronov Serge, Mamanova Lira, Rosic Andrej, Ju Young Seok, Cooke Susanna L, Ramakrishna Manasa, Papaemmanuil Elli, Davies Helen R, Tarpey Patrick S, Van Loo Peter, Wedge David C, Jones David R, Martin Sancha, Marshall John, Anderson Elizabeth, Hardy Claire, Barbashina Violetta, Aparicio Samuel A J R, Sauer Torill, Garred Øystein, Vincent-Salomon Anne, Mariani Odette, Boyault Sandrine, Fatima Aquila, Langerød Anita, Borg Åke, Thomas Gilles, Richardson Andrea L, Børresen-Dale Anne-Lise, Polyak Kornelia, Stratton Michael R, Campbell Peter J
Abstract excerpt
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pipeline for analyzing RNA sequencing data, which we integrated with whole genomes from 23 breast cancers. Using...
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