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Sox2 Suppresses Gastric Tumorigenesis in Mice

1 Aug 2016

Abstract excerpt

Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority of Sox2 targets in gastric epithelial cells are tissue specific and related to functions such as endoderm development, Wnt signaling, and gastric cancer....

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PMID: 27498859
DOI: 10.1016/j.celrep.2016.07.034

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