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Article

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.

Differentiation; research in biological diversity - 1 Feb 2011

Mutoh Hiroyuki, Sashikawa Miho, Sugano Kentaro

Abstract excerpt

Sox2 is closely related to the gastric phenotype. Sox2 plays a pivotal role in gastric epithelial differentiation in the adult. Sox2 expression is reduced in Helicobacter pylori-associated intestinal metaplastic change of the gastric epithelium. The gastric mucosa is replaced by intestinal metaplastic mucosa in the stomach of caudal type homeobox 2 (Cdx2)-transgenic mice. The aim of this study was to use...

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PMID: 21036460
DOI: 10.1016/j.diff.2010.10.002

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