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Article

Nuclear trafficking in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

6 Aug 2016

Abstract excerpt

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are two ends of a phenotypic spectrum of disabling, relentlessly progressive and ultimately fatal diseases. A key characteristic of both conditions is the presence of TDP-43 (encoded by TARDBP) or FUS immunoreactive cytoplasmic inclusions in neuronal and glial cells. This cytoplasmic mislocalization of otherwise predominantly nuclear RNA binding...

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PMID: 27497493
DOI: 10.1093/brain/aww197

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