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Article

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases.

Neuron - 11 Oct 2017

Kim Hong Joo, Taylor J Paul

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by degeneration of upper and lower motor neurons in the brain and spinal cord. The hallmark pathological feature in most cases of ALS is nuclear depletion and cytoplasmic accumulation of the protein TDP-43 in degenerating neurons. Consistent with this pattern of intracellular protein redistribution, impaired...

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Identifiers

PMID: 29024655
DOI: 10.1016/j.neuron.2017.07.029
PMCID: PMC5678982

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