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Inside out: the role of nucleocytoplasmic transport in ALS and FTLD

6 Jun 2016

Abstract excerpt

Neurodegenerative diseases are characterized by the presence of protein inclusions with a different protein content depending on the type of disease. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are no exceptions to this common theme. In most ALS and FTLD cases, the predominant pathological species are RNA-binding proteins. Interestingly, these proteins are both depleted from...

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PMID: 27271576
DOI: 10.1007/s00401-016-1586-5

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