Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.

doi:10.1093/cvr/cvw185

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Article

Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.

Cardiovascular research - 1 Oct 2016

Seidlmayer Lea K, Kuhn Johannes, Berbner Annette, Arias-Loza Paula-Anahi, Williams Tatjana, Kaspar Mathias, Czolbe Martin, Kwong Jennifer Q, Molkentin Jeffery D, Heinze Katrin Gertrud, Dedkova Elena N, Ritter Oliver

Abstract excerpt

AIMS: Elevated levels of inositol 1,4,5-trisphosphate (IP3) in adult cardiac myocytes are typically associated with the development of cardiac hypertrophy, arrhythmias, and heart failure. IP3 enhances intracellular Ca(2+ )release via IP3 receptors (IP3Rs) located at the sarcoplasmic reticulum (SR...

Topics

Adenosine Triphosphate
Animals
Calcium Channel Agonists
Calcium Channel Blockers
Calcium Signaling
Electric Stimulation
Endothelin-1
Genotype
Inositol 1,4,5-Trisphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inositol 1,4,5-Trisphosphate Receptors

Isoproterenol

Membrane Potential, Mitochondrial

Mice, Transgenic

Mitochondria, Heart

Myocytes, Cardiac

Phenotype

Reactive Oxygen Species

Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 27496868
DOI: 10.1093/cvr/cvw185
PMCID: PMC11154670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27496868-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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