Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration.

Aging - 21 Sept 2016

Choi Jeong Yi, Hwang Chae Young, Lee Bora, Lee Seung-Min, Bahn Young Jae, Lee Kwang-Pyo, Kang Moonkyung, Kim Yeon-Soo, Woo Sun-Hee, Lim Jae-Young, Kim Eunhee, Kwon Ki-Sun

Abstract excerpt

Skeletal muscle mass and power decrease with age, leading to impairment of mobility and metabolism in the elderly. Ca2+ signaling is crucial for myoblast differentiation as well as muscle contraction through activation of transcription factors and Ca2+-dependent kinases and phosphatases. Ca2+ channels, such as dihydropyridine receptor (DHPR), two-pore channel (TPC) and inositol 1,4,5-triphosphate receptor (ITPR),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Inositol 1,4,5-Trisphosphate Receptors

Share to Muscle Development

Share to Muscle, Skeletal

Share to Myoblasts

Share to Regeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 27658230
DOI: 10.18632/aging.101039
PMCID: PMC5076452

Genes

ITPR1
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration.PMID 27658230Read ↗

PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle agingSemantic proximity Read ↗

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.Semantic proximity Read ↗

Ryanodine receptor 1 ( <i>RYR1</i> ) patient-derived muscle cells recapitulate disease phenotypes in 2D and 3D culture modelsSemantic proximity Read ↗

IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic miceSemantic proximity Read ↗

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.Semantic proximity Read ↗

Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure.Semantic proximity Read ↗

IRE1α regulates skeletal muscle regeneration through myostatin mRNA decaySemantic proximity Read ↗

Pathophysiological consequences of isoform-specific IP3 receptor mutations.Semantic proximity Read ↗

DMD Human iPSC-derived skeletal muscle cells recapitulate selective calcium dysregulation pathwaysSemantic proximity Read ↗

Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and diseaseSemantic proximity Read ↗

A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity.Semantic proximity Read ↗

RyR1 deficiency in congenital myopathies disrupts excitation-contraction coupling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.