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Article

Functional local crosstalk of inositol 1,4,5-trisphosphate receptor- and ryanodine receptor-dependent Ca2+ release in atrial cardiomyocytes.

Cardiovascular research - 1 Apr 2017

Wullschleger Marcel, Blanch Joaquim, Egger Marcel

Abstract excerpt

AIMS: Enhanced inositol 1,4,5-trisphosphate receptor (InsP3R2) expression has been associated with a variety of proarrhythmogenic cardiac disorders. The functional interaction between the two major Ca2+ release mechanisms in cardiomyocytes, Ca2+ release mediated by ryanodine receptors (RyR2s) and InsP3-induced intracellular Ca2+ release (IP3ICR) remains enigmatic. We aimed at identifying characterizing local...

Topics

Animals
Calcium Signaling
Electric Stimulation
Endothelin-1
Heart Atria
Image Processing, Computer-Assisted
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Mice, Inbred C57BL
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Confocal

Myocardial Contraction

Myocytes, Cardiac

Phenotype

Receptor Cross-Talk

Ryanodine Receptor Calcium Release Channel

Sarcoplasmic Reticulum

Time Factors

Source

Identifiers

PMID: 28158491
DOI: 10.1093/cvr/cvx020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28158491-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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