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Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing

16 Apr 2012

Abstract excerpt

BACKGROUND AND AIMS: Although the advent of ultra-deep sequencing technology allows for the analysis of heretofore-undetectable minor viral mutants, a limited amount of information is currently available regarding the clinical implications of hepatitis B virus (HBV) genomic heterogeneity. METHODS: To characterize the HBV genetic heterogeneity in association with anti-viral therapy, we performed ultra-deep...

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PMID: 22523569
DOI: 10.1371/journal.pone.0035052

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