Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

Liver international : official journal of the International Association for the Study of the Liver - 1 Nov 2012

Zheng Jinxin, Zeng Zheng, Zhang Duyi, Yu Yanyan, Wang Fang, Pan Calvin Q

Abstract excerpt

AIMS: Hepatitis B virus (HBV) reverse transcriptase (RT) mutants, which have not been well characterized according to different disease stages. This study aimed to characterize the profiles of naturally occurring mutations in the HBV RT region and their associated clinical outcomes. METHODS: HBV RT region mutations and genotypes were determined by PCR-direct sequencing and compared with p-distance model. RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Hepatitis B virus

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to RNA-Directed DNA Polymerase

Share to Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 22882650
DOI: 10.1111/j.1478-3231.2012.02859.x
PMCID: PMC3463715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.PMID 22882650Read ↗

Accumulation of mutations in reverse transcriptase of hepatitis B virus is associated with liver disease severity in treatment-naïve Chinese patients with chronic hepatitis B.Semantic proximity Read ↗

Different Variants in Reverse Transcriptase Domain Determined by Ultra-deep Sequencing in Treatment-naïve and Treated Indonesian Patients Infected with Hepatitis B Virus.Semantic proximity Read ↗

rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 GenomeSemantic proximity Read ↗

Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.Semantic proximity Read ↗

Effect of mutations across reverse transcriptase region on HBV replication and progression of liver diseases in Chinese patients.Semantic proximity Read ↗

Mutations in reverse transcriptase region of HBV affect Hepatitis B surface antigen titers and its correlation with HBV DNA.Semantic proximity Read ↗

Overview of hepatitis B virus mutations and their implications in the management of infection.Semantic proximity Read ↗

Hepatitis B virus genotypes influence clinical outcomes: A reviewSemantic proximity Read ↗

Characterization of mutations in the reverse transcriptase region of hepatitis B virus in treated and untreated chronic hepatitis B patients.Semantic proximity Read ↗

rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C InfectionsSemantic proximity Read ↗

Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment-naïve Korean patients infected with genotype C2.Semantic proximity Read ↗

Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.