Article
Early changes in quasispecies variant after antiviral therapy for chronic hepatitis B.
Molecular medicine reports - 1 Apr 2018
Liang Yujiao, Yano Yoshihiko, Putri Wahyu Aristyaning, Mardian Yan, Okada Rina, Tanahashi Toshihito, Murakami Yoshiki, Hayashi Yoshitake
Abstract excerpt
Hepatitis B virus (HBV) polymerase gene is targeted by nucleos(t)ide analogues (NUC), but it is unclear how HBV quasispecies of whole genome changes during early period of NUC treatment. To understand the unknown region of drug sensitivity and treatment resistance, HBV quasispecies of whole genome during early period of NUC treatment was examined using ultra‑deep sequencing. Eleven patients with chronic HBV...
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