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Article

Action of Pasteurella multocida toxin depends on the helical domain of Galphaq.

The Journal of biological chemistry - 13 Aug 2004

Orth Joachim H C, Lang Simona, Aktories Klaus

Abstract excerpt

Pasteurella multocida produces a 146-kDa protein toxin (PMT), which activates multiple cellular signal transduction pathways, resulting in the activation of phospholipase Cbeta, RhoA, Jun kinase, and extracellular signal-regulated kinase. Using Galpha(q)/Galpha(11) -deficient cells, it was shown that the PMT-induced pleiotropic effects are mediated by Galpha(q) but not by the highly related Galpha(11) protein...

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Identifiers

PMID: 15192096
DOI: 10.1074/jbc.M405353200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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