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Article

Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis.

PloS one - 17 May 2010

Papatheodorou Panagiotis, Zamboglou Constantinos, Genisyuerek Selda, Guttenberg Gregor, Aktories Klaus

Abstract excerpt

Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C. novyi alpha-toxin (TcnA) are important pathogenicity factors, which represent the family of the clostridial glucosylating toxins (CGTs). Toxin A and B are associated with antibiotic-associated diarrhea and pseudomembraneous colitis. Lethal toxin is involved in toxic shock syndrome after abortion and alpha-toxin in gas...

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Identifiers

PMID: 20498856
DOI: 10.1371/journal.pone.0010673
PMCID: PMC2871790

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