Article
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010
Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh J-E, Gal-Toth J, Lee F, Toth M
Abstract excerpt
Low serotonin(1A) receptor (5-HT(1A)R) binding is a risk factor for anxiety and depression, and deletion of the 5-HT(1A)R results in anxiety-like behavior in mice. Here we show that anxiety-like behavior in mice also can be caused, independently of the offspring's own 5-HT(1A)R genotype, by a receptor deficit in the mother: a nongenetic transmission of a genetic defect. Some of the nongenetically transmitted...
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