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Article

Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions.

Nature communications - 4 Aug 2016

Di Roberto Raphaël B, Chang Belinda, Trusina Ala, Peisajovich Sergio G

Abstract excerpt

All cellular functions depend on the concerted action of multiple proteins organized in complex networks. To understand how selection acts on protein networks, we used the yeast mating receptor Ste2, a pheromone-activated G protein-coupled receptor, as a model system. In Saccharomyces cerevisiae, Ste2 is a hub in a network of interactions controlling both signal transduction and signal suppression. Through...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27487915
DOI: 10.1038/ncomms12344
PMCID: PMC4976203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions.PMID 27487915Read ↗

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