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A functionally significant SNP in TP53 and breast cancer risk in African-American women

21 Feb 2017

Abstract excerpt

Abstract A coding region polymorphism exists in the TP53 gene (Pro47Ser; rs1800371) in individuals of African descent, which reduces p53 tumor suppressor function in a mouse model. It has been unclear whether this functionally significant polymorphism alters cancer risk in humans. This analysis included 6907 women with breast cancer and 7644 controls from the AMBER, ROOT, and AABC consortia. We used multivariable...

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PMID: 28649645
DOI: 10.1038/s41523-017-0007-9

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