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Article

Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Cancer research - 1 Oct 2018

Barnoud Thibaut, Budina-Kolomets Anna, Basu Subhasree, Leu Julia I-Ju, Good Madeline, Kung Che-Pei, Liu Jingjing, Liu Qin, Villanueva Jessie, Zhang Rugang, George Donna L, Murphy Maureen E

Abstract excerpt

The tumor suppressor TP53 is the most frequently mutated gene in human cancer and serves to restrict tumor initiation and progression. Single-nucleotide polymorphisms (SNP) in TP53 and p53 pathway genes can have a marked impact on p53 tumor suppressor function, and some have been associated with increased cancer risk and impaired response to therapy. Approximately 6% of Africans and 1% of African Americans...

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Identifiers

PMID: 30115697
DOI: 10.1158/0008-5472.CAN-18-1327
PMCID: PMC6168343

Genes

PIN1

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