Article
Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Nov 2015
Phang Beng Hooi, Othman Rashidah, Bougeard Gaelle, Chia Ren Hui, Frebourg Thierry, Tang Choong Leong, Cheah Peh Yean, Sabapathy Kanaga
Abstract excerpt
Whereas most mutations in p53 occur in the DNA-binding domain and lead to its functional inactivation, their relevance in the amino-terminal transactivation domain is unclear. We show here that amino-terminal p53 (ATp53) mutations often result in the abrogation of full-length p53 expression, but concomitantly lead to the expression of the amino-terminally truncated p47 isoform. Using genetically modified cancer...
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