Article
A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Apr 2020
Moorehead Amy, Hanna Raphael, Heroux Delia, Neighbour Helen, Sandford Andrew, Gauvreau Gail M, Sommer Doron D, Denburg Judah A, Akhabir Loubna
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified associations of the single nucleotide polymorphism rs1837253 in the thymic stromal lymphopoietin (TSLP) gene with asthma, allergic disease and eosinophilia. The TSLP gene encodes two isoforms, long and short, and previous studies have indicated functional differences between these two isoforms. OBJECTIVE: We investigated the expression of these TSLP...
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