Article
Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.
American journal of respiratory cell and molecular biology - 1 Jun 2011
Harada Michishige, Hirota Tomomitsu, Jodo Aya I, Hitomi Yuki, Sakashita Masafumi, Tsunoda Tatsuhiko, Miyagawa Takehiko, Doi Satoru, Kameda Makoto, Fujita Kimie, Miyatake Akihiko, Enomoto Tadao, Noguchi Emiko, Masuko Hironori, Sakamoto Tohru, Hizawa Nobuyuki, Suzuki Yoichi, Yoshihara Shigemi, Adachi Mitsuru, Ebisawa Motohiro, Saito Hirohisa, Matsumoto Kenji, Nakajima Toshiharu, Mathias Rasika A, Rafaels Nicholas, Barnes Kathleen C, Himes Blanca E, Duan Qing Ling, Tantisira Kelan G, Weiss Scott T, Nakamura Yusuke, Ziegler Steven F, Tamari Mayumi
Abstract excerpt
Thymic stromal lymphopoietin (TSLP) triggers dendritic cell--mediated T helper (Th) 2 inflammatory responses. A single-nucleotide polymorphism (SNP), rs3806933, in the promoter region of the TSLP gene creates a binding site for the transcription factor activating protein (AP)-1. The variant enhances AP-1 binding to the regulatory element, and increases the promoter--reporter activity of TSLP in response to...
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