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Article

Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2014

Javaheri Behzad, Stern Amber Rath, Lara Nuria, Dallas Mark, Zhao Hong, Liu Ying, Bonewald Lynda F, Johnson Mark L

Abstract excerpt

The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β-catenin haploinsufficient mice (Dmp1-Cre × β-catenin fl/ + ; HET cKO) were compared with their β-catenin fl/fl (control) littermates. Trabecular bone volume (BV/TV)...

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PMID: 23929793
DOI: 10.1002/jbmr.2064
PMCID: PMC4171742

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