Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene.

The Journal of clinical investigation - 1 Dec 2002

Hoff Ana O, Catala-Lehnen Philip, Thomas Pamela M, Priemel Matthias, Rueger Johannes M, Nasonkin Igor, Bradley Allan, Hughes Mark R, Ordonez Nelson, Cote Gilbert J, Amling Michael, Gagel Robert F

Abstract excerpt

Calcitonin (CT) is a known inhibitor of bone resorption. Calcitonin gene-related peptide-alpha (CGRPalpha), produced by alternative RNA processing of the CT/CGRP gene, has no clearly defined role in bone. To better understand the physiologic role of the CT/CGRP gene we created a mouse in which the coding sequences for both CT and CGRPalpha were deleted by homologous recombination. The CT/CGRP(-/-) knockout (KO)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Resorption
Share to Calcitonin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcitonin Gene-Related Peptide

Share to Estrogens

Share to Osteoclasts

Share to Ovariectomy

Share to Parathyroid Hormone

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 12488435
DOI: 10.1172/JCI14218
PMCID: PMC151647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene.PMID 12488435Read ↗

Calcitonin Deficiency in Mice Progressively Results in High Bone TurnoverSemantic proximity Read ↗

Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide.Semantic proximity Read ↗

Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice.Semantic proximity Read ↗

Targeted Expression of Calcitonin Gene-Related Peptide to Osteoblasts Increases Bone Density in MiceSemantic proximity Read ↗

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.Semantic proximity Read ↗

The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation.Semantic proximity Read ↗

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.Semantic proximity Read ↗

The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption.Semantic proximity Read ↗

The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism.Semantic proximity Read ↗

Inhibition of miR-29 Activity in the Myeloid Lineage Increases Response to Calcitonin and Trabecular Bone Volume in Mice.Semantic proximity Read ↗

Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus.Semantic proximity Read ↗

Increased bone formation in osteocalcin-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.