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Article

OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression.

Molecular and cellular biology - 15 Oct 2016

Ding Zonghui, Liu Yue, Rubio Valentina, He Jinjie, Minze Laurie J, Shi Zheng-Zheng

Abstract excerpt

OLA1, an Obg-family GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translational control, but its physiological functions remain obscure. Here we report that mouse embryos lacking OLA1 have stunted growth, delayed development leading to immature organs-especially lungs-at birth, and frequent perinatal lethality. Proliferation of primary Ola1(-/-) mouse embryonic fibroblasts (MEFs)...

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Identifiers

PMID: 27481995
DOI: 10.1128/MCB.00137-16
PMCID: PMC5038148

Genes

OLA1

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