Article
First Membrane Proximal External Region-Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2016
Benjelloun Fahd, Oruc Zeliha, Thielens Nicole, Verrier Bernard, Champier Gael, Vincent Nadine, Rochereau Nicolas, Girard Alexandre, Jospin Fabienne, Chanut Blandine, Genin Christian, Cogné Michel, Paul Stephane
Abstract excerpt
Mucosal HIV-1-specific IgA have been described as being able to neutralize HIV-1 and to block viral transcytosis. In serum and saliva, the anti-HIV IgA response is predominantly raised against the envelope of HIV-1. In this work, we describe the in vivo generation of gp41-specific IgA1 in humanized α1KI mice to produce chimeric IgA1. Mice were immunized with a conformational immunogenic gp41-transfected cell...
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