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Article

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.

PloS one - 1 Jan 2014

Hwang Kwan-Ki, Trama Ashley M, Kozink Daniel M, Chen Xi, Wiehe Kevin, Cooper Abby J, Xia Shi-Mao, Wang Minyue, Marshall Dawn J, Whitesides John, Alam Munir, Tomaras Georgia D, Allen Steven L, Rai Kanti R, McKeating Jane, Catera Rosa, Yan Xiao-Jie, Chu Charles C, Kelsoe Garnett, Liao Hua-Xin, Chiorazzi Nicholas, Haynes Barton F

Abstract excerpt

B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases. Since HIV-1 envelope gp41 antibodies also frequently use IGHV1-69 gene segments, we hypothesized that IGHV1-69 B-CLL precursors may contribute to the gp41 B cell response during HIV-1 infection. To test this hypothesis, we rescued 5...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24614505
DOI: 10.1371/journal.pone.0090725
PMCID: PMC3948690

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.PMID 24614505Read ↗

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