Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal Mucosa

9 Oct 2010

Abstract excerpt

The gut mucosal surface is efficiently protected by Abs, and this site represents one of the richest compartments of Ab-secreting cells in the body. A simple and effective method to generate Ag-specific human monoclonal Abs (hmAbs) from such cells is lacking. In this paper, we describe a method to generate hmAbs from single Ag-specific IgA- or IgM-secreting cells of the intestinal mucosa. We found that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20935207
DOI: 10.4049/jimmunol.1001587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal MucosaPMID 20935207Read ↗

Generation of recombinant human monoclonal antibodies to rotavirus from single antigen-specific B cells selected with fluorescent virus-like particlesSemantic proximity Read ↗

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tractSemantic proximity Read ↗

Functional Maturation of the Human Antibody Response to RotavirusSemantic proximity Read ↗

Immunodominance of the VH1–46 Antibody Gene Segment in the Primary Repertoire of Human Rotavirus-Specific B Cells Is Reduced in the Memory Compartment through Somatic Mutation of Nondominant ClonesSemantic proximity Read ↗

Human rotavirus-specific IgM Memory B cells have differential cloning efficiencies and switch capacities and play a role in antiviral immunity in vivo.Semantic proximity Read ↗

Monoclonal Antibody Therapeutics for Infectious Diseases: Beyond Normal Human ImmunoglobulinSemantic proximity Read ↗

Differential transcriptome and development of human peripheral plasma cell subsetsSemantic proximity Read ↗

Norovirus-specific monoclonal antibodies that block histo-blood group antigen binding isolated from healthy donors.Semantic proximity Read ↗

A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery.Semantic proximity Read ↗

CellCelector™ as a platform in isolating primary B cells for antibody discoverySemantic proximity Read ↗

Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes.Semantic proximity Read ↗

Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.