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Article

Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene.

Archives of biochemistry and biophysics - 15 Sept 2016

Borovikov Yurii S, Rysev Nikita A, Chernev Aleksey A, Avrova Stanislava V, Karpicheva Olga E, Borys Danuta, Śliwińska Małgorzata, Moraczewska Joanna

Abstract excerpt

Amino acid substitutions: Arg167His, Arg167Gly and Lys168Glu, located in a consensus actin-binding site of the striated muscle tropomyosin Tpm1.1 (TM), were used to investigate mechanisms of the thin filament regulation. The azimuthal movement of TM strands on the actin filament and the responses of the myosin heads and actin subunits during the ATPase cycle were studied using fluorescence polarization of muscle...

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Identifiers

PMID: 27480605
DOI: 10.1016/j.abb.2016.07.022

Genes

TPM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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