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Article

Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.

Archives of biochemistry and biophysics - 1 Jul 2015

Borovikov Yurii S, Avrova Stanislava V, Rysev Nikita A, Sirenko Vladimir V, Simonyan Armen O, Chernev Aleksey A, Karpicheva Olga E, Piers Adam, Redwood Charles S

Abstract excerpt

We have investigated the effect of the E41K, R91G, and E139del β-tropomyosin (TM) mutations that cause congenital myopathy on the position of TM and orientation of actin monomers and myosin heads at different mimicked stages of the ATPase cycle in troponin-free ghost muscle fibers by polarized fluorimetry. A multi-step shifting of wild-type TM to the filament center accompanied by an increase in the amount of...

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PMID: 25978979
DOI: 10.1016/j.abb.2015.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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