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Article

The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2.

Biochemical and biophysical research communications - 26 Feb 2020

Borovikov Yurii S, Karpicheva Olga E, Avrova Stanislava V, Simonyan Armen O, Sirenko Vladimir V, Redwood Charles S

Abstract excerpt

Ghost muscle fibres reconstituted with myosin heads labeled with the fluorescent probe 1,5-IAEDANS were used for analysis of muscle fibre dysfunction associated with the R133W mutation in β-tropomyosin (Tpm2.2). By using polarized microscopy, we showed that at high Ca2+ the R133W mutation in both αβ-Tpm heterodimers and ββ-Tpm homodimers decreases the amount of the myosin heads strongly bound to F-actin and the...

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PMID: 31864708
DOI: 10.1016/j.bbrc.2019.12.061

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