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Article

The E117K mutation in β-tropomyosin disturbs concerted conformational changes of actomyosin in muscle fibers.

Archives of biochemistry and biophysics - 1 May 2014

Karpicheva Olga E, Redwood Charles S, Borovikov Yurii S

Abstract excerpt

The effect of the skeletal myopathy-causing E117K mutation in human β-tropomyosin on actomyosin structure during the ATPase cycle was studied using fluorescent probes bound to actin subdomain 1 and the myosin head. Multistep changes in flexural rigidity of actin filament and in spatial arrangement of actin subdomain 1 and myosin SH1 helix in troponin-free ghost muscle fibers were revealed. During the ATPase cycle...

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Source

Identifiers

PMID: 24657080
DOI: 10.1016/j.abb.2014.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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