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Article

Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle.

Biochemical and biophysical research communications - 10 Apr 2009

Borovikov Yurii S, Karpicheva Olga E, Chudakova Galina A, Robinson Paul, Redwood Charles S

Abstract excerpt

The Glu40Lys and Glu54Lys mutations in alpha-tropomyosin cause dilated cardiomyopathy (DCM). Functional analysis has demonstrated that both mutations decrease thin filament Ca2+-sensitivity and that Glu40Lys reduces maximum activation. To understand the molecular mechanism underlying these changes, we labeled wild type alpha-tropomyosin and both mutants at Cys190 with 5-iodoacetamide-fluorescein and incorporated...

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Identifiers

PMID: 19222994
DOI: 10.1016/j.bbrc.2009.02.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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